Publications
Our most recent Edinburgh Metabolism publications
Clinical implications of bone marrow adiposity identified by phenome-wide association and Mendelian randomization in the UK Biobank
Wei Xu, Ines Mesa-Eguiagaray, David M Morris, Chengjia Wang, Calum D Gray, Samuel Sjöström, Giorgos Papanastasiou, Sammy Badr, Julien Paccou, Lijuan Wang, Xue Li, Paul R H J Timmers, Maria Timofeeva, Scott Ik Semple, Tom MacGillivray, Evropi Theodoratou, William P Cawthorn
Nat Commun. 2025 Sep 23;16(1):8332
PMID: 40987763
Impact of Omnipod 5 automated insulin delivery on continuous glucose monitoring metrics and predictors of improvement in time in range
Roland H Stimson, Mark W J Strachan, Shareen Forbes, Rohana J Wright, Scott D Mackenzie, Gayle McRobert, Emily M McMurray, Marcus J Lyall, Anna R Dover, Fraser W Gibb
Diabet Med. 2025 Sep 9:e70137
PMID: 40925746
Society for Endocrinology Clinical Practice Guideline for the Evaluation of Androgen Excess in Women
Yasir S Elhassan, James M Hawley, Leanne Cussen, Ali Abbara, Sophie A Clarke, Punith Kempegowda, Rima K Dhillon-Smith, Puja Thadani, Maureen Busby, Lucy Owusu-Darkwah, Rachel Marrington, W Colin Duncan, Robert K Semple, Richard Quinton, Michael W O'Reilly
Clin Endocrinol (Oxf). 2025 Oct;103(4):540-566
PMID: 40364581
Experimental analysis of bone marrow adipose tissue and bone marrow adipocytes: An update from the bone marrow adiposity society (BMAS)
Michaela Tencerova, Biagio Palmisano, Stéphanie Lucas, Camille Attané, Kaisa K Ivaska, Léa Loisay, Yoshiko M Ikushima, Drenka Trivanovic, Alessandro Corsi, Adriana Roque, Hongshuai Li, Friederike Behler-Janbeck, Jeroen Geurts, Mara Riminucci, Izabela Podgorski, William P Cawthorn, Bram C J van der Eerden, André J van Wijnen
Bone Rep. 2025 Jul 28:26:101861
PMID: 40837072
Identification of a molecular resistor that controls UCP1-independent Ca2+ cycling thermogenesis in adipose tissue
Christopher Auger, Mark Li, Masanori Fujimoto, Kenji Ikeda, Jin-Seon Yook, Timothy R O'Leary, María Paula Huertas Caycedo, Cai Xiaohan, Satoshi Oikawa, Anthony R P Verkerke, Kosaku Shinoda, Patrick R Griffin, Kenji Inaba, Roland H Stimson, Shingo Kajimura
Cell Metab. 2025 Jun 3;37(6):1311-1325.e9
PMID: 40199326
Insulin receptor variants: Extending the traditional Mendelian spectrum
Delphine Collin-Chavagnac, Cécile Saint-Martin, Lotfi Bedidi, Louis Lebreton, Vahid Aslanzadeh, Corinne Vigouroux, Christine Bellanné-Chantelot, Robert K Semple, Olivier Lascols, Isabelle Jéru
Genet Med. 2025 Jun;27(6):101404
PMID: 40094207
RNA-binding proteins DND1 and NANOS3 cooperatively suppress the entry of germ cell lineage
Ziqi Wang, Honglin Yu, Zhaoyu Gu, Xiaohui Shi, Jiayue Ma, Qizhe Shao, Yao Yao, Shuo Yao, Yan Xu, Yashi Gu, Jiayue Dai, Qi Liu, Jingyan Shi, Rujie Qi, Yue Jin, Yuqian Liu, Xinchen Shen, Wenwen Huang, Heng-Jia Liu, Min Jin, Wanlu Liu, Matthew Brook, Di Chen
Nat Commun. 2025 May 23;16(1):4792
PMID: 40410171
Functional Beta Cell Mass >40% Predicts Long Term Insulin Independence to 6 Years Following Human Islet Transplantation: Lessons to Guide Clinical Practice.
Shareen Forbes.
Diabetes, In Press, Feb 2025
PMID: TBC
The NE/AAT/CBG axis regulates adipose glucocorticoid exposure.
Luke D Boyle, Allende Miguelez-Crespo, Mhairi Paul, Elisa Villalobos, Julia NC Toews, Lisa Ivatt, Boglarka Nagy, Marisa Magennis, Natalie ZM Homer, Ruth Andrew, Victor Viau, Geoffrey L Hammond, Roland H Stimson, Brian R Walker & Mark Nixon.
Nat Communications. 2025 Jan 9;16(1):545
PMID: 39788946
Deep learning and genome-wide association meta-analyses of bone marrow adiposity in the UK Biobank
Wei Xu, Ines Mesa-Eguiagaray, David M. Morris, Chengjia Wang, Calum D. Gray, Samuel Sjöström, Giorgos Papanastasiou, Sammy Badr, Julien Paccou, Xue Li, Paul R. H. J. Timmers, Maria Timofeeva, Susan M. Farrington, Malcolm G. Dunlop, Scott I. Semple, Tom MacGillivray, Evropi Theodoratou & William P. Cawthorn.
Nat Communications. 2025 Jan 2;16(1):99
PMID: 39747859
Spatial lipidomic profiles of atherosclerotic plaques: A mass spectrometry imaging study.
Sphamandla Ntshangase, Shazia Khan, Louise Bezuidenhout, TaÅ¥ána Gazárková, Jakub Kaczynski, Stephanie Sellers, Nicholas Jw Rattray, David E Newby, Patrick Wf Hadoke, Ruth Andrew
Talanta. 2025 Jan 1:282:126954.
PMID: 39423636
Proof of concept for a superior therapeutic index of corticosterone compared with hydrocortisone in patients with congenital adrenal hyperplasia.
Catriona J Kyle, Luke D Boyle, Mark Nixon, Natalie ZM Homer, Joanna P Simpson, Alison Rutter, Lynne E Ramage, Alex Kelman, Ellen M Freel, Ruth Andrew, Brian R Walker, Roland H Stimson.
Eur J Endocrinol. 2024 Nov 27;191(6):535-544
PMID: 39546623
Preterm birth as a determinant of neurodevelopment and cognition in children (PRENCOG): protocol for an exposure-based cohort study in the UK.
James P Boardman, Ruth Andrew, Mark E Bastin, Cheryl Battersby, G David Batty, Manuel Blesa Cábez, Simon R Cox, Jill Hall, Lauren Ingledow, Riccardo E Marioni, Neena Modi, Lee Murphy, Alan J Quigley, Rebecca M Reynolds, Hilary Richardson, Sarah J Stock, Michael J Thrippleton, Athanasios Tsanas, Heather C Whalley
BMJ Open. 2024 Sep 16;14(9):e085365.
PMID: 39284691
ATP-binding cassette family C member 1 constrains metabolic responses to high-fat diet.
Elisa Villalobos, Allende Miguelez-Crespo, Ruth A Morgan, Lisa Ivatt, Mhairi Paul, Joanna P Simpson, Natalie ZM Homer, Dominic Kurian, Judit Aguilar, Rachel Kline, T Wishart, Nicholas Morton, Roland H Stimson, Ruth Andrew, Brian R Walker, Mark Nixon.
J Endocrinol. 2024 Jun 1:JOE-24-0024.
PMID: 38829241
A cross-sectional questionnaire study: Impaired awareness of hypoglycaemia remains prevalent in adults with type 1 diabetes and is associated with the risk of severe hypoglycaemia
Faye Baxter, Nicola Baillie, Anna Dover, Roland H Stimson, Fraser Gibb, Shareen Forbes.
PLoS One. 2024 Jun 14;19(6):e0297601
PMID: 38875308
Mesenchymal-specific Alms1 knockout in mice recapitulates metabolic features of Alström syndrome.
Eleanor J McKay, Ineke Luijten, Xiong Weng, Pablo B Martinez de Morentin, Elvira De Frutos González, Zhanguo Gao, Mikhail G Kolonin, Lora K Heisler, Robert K Semple.
Mol Metab. 2024 Jun:84:101933
PMID: 38583571
Deletion of Hsd11b1 suppresses caloric-restriction-induced bone marrow adiposity in male but not female mice.
Andrea Lovdel, Karla Suchacki, Fiona Roberts, Richard J Sulston, Robert J Wallace, Benjamin J Thomas, Rachel M B Bell, Iris Pruñonosa Cervera, Gavin Macpherson, Nicholas Morton, Natalie ZM Homer, Karen E Chapman, William P Cawthorn.
J Endocrinol. 2024 May 1:JOE-24-0072.
PMID: 38805506
Impact of COVID-19 on gestational diabetes pregnancy outcomes in the UK: A multicentre retrospective cohort study
Niamh-Maire Mclennan, Robert Lindsay, Ponnusamy Saravanan, Nithya Sukumar, Sara L White, Peter von Dadelszen, Christy Burden, Kathryn Hunt, Priya George, Jane E Hirst, Katherine Lattey, Tara T M Lee, Helen R Murphy, Eleanor M Scott, Laura A Magee, Rebecca M Reynolds; Diabetes in Pregnancy Working Group.
BJOG. 2024 May;131(6):858-868
PMID: 37968246
Plasma steroid concentrations reflect acute disease severity and normalise during recovery in people hospitalised with COVID-19
Kerri Devine, Clark D Russell, Giovanny R Blanco, Brian R Walker, Natalie ZM Homer, Scott G Denham, Joanna P Simpson , Olivia C Leavy, Omer Elneima, Hamish J C McAuley, Aarti Shikotra, Amisha Singapuri, Marco Sereno, Ruth M Saunders , Victoria C Harris, Linzy Houchen-Wolloff, Neil J Greening, Nazir I Lone, Mathew Thorpe, William Greenhalf, James D Chalmers, Ling-Pei Ho, Alex Horsley, Michael Marks, Betty Raman, Shona C Moore, Jake Dunning, Malcolm G Semple, Ruth Andrew, Louise V Wain, Rachael A Evans, Christopher E Brightling, John Kenneth Baillie, Rebecca M Reynolds; ISARIC4C Investigators and PHOSP-COVID Study Collaborative Group.
Clin Endocrinol (Oxf). 2024 Apr;100(4):317-327.
PMID: 38229583
A novel deep learning method for large-scale analysis of bone marrow adiposity using UK Biobank Dixon MRI data
David M Morris, Chengjia Wang, Giorgos Papanastasiou, Calum D Gray, Wei Xu, Samuel Sjöström, Sammy Badr, Julien Paccou, Scott Semple, Tom MacGillivray, William P Cawthorn.
Comput Struct Biotechnol J. 2023 Dec 27:24:89-104.
PMID: 38268780