Diabetes: Drivers & Therapeutics

Revealing new knowledge of beta cell function and insulin action to improve human health

To identify the molecular mechanisms underpinning beta cell destruction and function.

To establish the molecular mechanisms underpinning insulin action and how these mechanisms are dysregulated in physiological and pathological contexts (eg diabetes, obesity and ageing).

To leverage this knowledge for improved strategies to prevent and treat Type 1 and Type 2 diabetes, cardiometabolic diseases and other chronic, age-related morbidities.

Mechanisms of diabetes remission.

Lipid metabolism and pancreas biology.

Steroid hormones as diabetic risk factors.

Ruth Andrew

Role of autoreactive antibodies in Type 2 Diabetes.

Optimising islet engraftment and long-term function using cell therapies and other co-therapies.

Studies with stem cell derived islets

Correcting the dysregulation of glucagon metabolism in response to hypoglycaemia in T1D.

Advancing Understanding of Blood Glucose Control in T1D: A Data Science Approach.

Shareen Forbes

Glucose metabolism and beta-cell function in Type 2 Diabetes.

Glucocorticoid-induced insulin resistance in adipose tissue and skeletal muscle.

Mark Nixon

Massive parallel functional scanning of insulin signalling genes.

Novel treatments for monogenic extreme insulin resistance.

Links between PI 3-Kinase signalling and metabolic syndrome.

Robert Semple