Research

Understanding the Drivers Of Cardiometabolic Diseases

Identify novel regulators of cardiometabolic diseases

Goals:

Understand how the immune, endocrine and nervous systems contribute to metabolic health.
Understand how dysregulation of these systems in obesity, diabetes and ageing contribute to the development of cardiometabolic diseases.
To leverage this knowledge for improved strategies to prevent and treat cardiometabolic diseases.

How steroid metabolism affects hormonal action in metabolic tissues. Influence of 5alpha reductase inhibitors on cardiometabolic risk factors.

Ruth Andrew ↗

Immune system, metabolism & obesity. B cell contribution to metabolic deregualtion in obesity & ageing. Macrophage & lipid transport.

Cécile Bénézech ↗

RNA-binding proteins in metabolic and cardiovascular health.

Matthew Brook ↗

Bone marrow adipose tissue, diet, ageing, & sex differences in health & disease.

Will Cawthorn ↗

Utilising zebrafish and genetic screens to identify molecular mechanisms of adipose formation, distribution and function.

James Minchin ↗

Glucocorticoid induced insulin resistance and cardiac remodelling. Obesity-induced vascular dysfunction.

Mark Nixon ↗

Epigenetics, development, and cell fate in cardiometabolic health and diseases.

Sari Pennings ↗

Brown adipose tissue formation and function, including human studies and new imaging methods.

Roland Stimson ↗

The nature of insulin resistance and its role as a mediator of cardiometabolic and reproductive complications of obesity.

Robert Semple ↗