Mechanisms of diabetes remission. Lipid metabolism and pancreas biology.
Ahmad Al-Mrabeh ↗Research
Diabetes: Drivers & Therapeutics
Revealing new knowledge of beta cell function and insulin action to improve human health
Goals:
To identify the molecular mechanisms underpinning beta cell destruction and function.
To establish the molecular mechanisms underpinning insulin action and how these mechanisms are dysregulated in physiological and pathological contexts (eg diabetes, obesity and ageing).
To leverage this knowledge for improved strategies to prevent and treat Type 1 and Type 2 diabetes, cardiometabolic diseases and other chronic, age-related morbidities.
Projects and Research Groups
Steroid hormones as diabetic risk factors.
Ruth Andrew ↗Role of autoreactive antibodies in Type 2 Diabetes.
Cécile Bénézech ↗Optimising islet engraftment and long-term function using cell therapies and other co-therapies. Studies with stem cell derived islets Correcting the dysregulation of glucagon metabolism in response to hypoglycaemia in T1D. Advancing Understanding of Blood Glucose Control in T1D: A Data Science Approach.
Shareen Forbes ↗Glucose metabolism and beta-cell function in Type 2 Diabetes.
Elizabeth Haythorne ↗Glucocorticoid-induced insulin resistance in adipose tissue and skeletal muscle.
Mark Nixon ↗Massive parallel functional scanning of insulin signalling genes. Novel treatments for monogenic extreme insulin resistance. Links between PI 3-Kinase signalling and metabolic syndrome.
Robert Semple ↗