Intra-organ fat deposition and pancreas lipotoxicity
Ahmad Al-Mrabeh ↗Research
Genetic and Molecular Determinants of Adipose Tissue Function
Revealing new knowledge of adipose tissue formation and function to improve human health
Goals:
To identify the molecular mechanisms underpinning adipose tissue formation, distribution, and function.
To establish how these mechanisms are (dys)regulated in physiological and pathological contexts such as obesity, diabetes, ageing, and caloric restriction.
To leverage this knowledge for improved strategies to prevent and treat cardiometabolic diseases and other chronic, age-related morbidities.
Projects and Research Groups
Structure of the mesothelium associated with adipose tissue. Immune function of Fat-associated lymphoid clusters.
Cécile Bénézech ↗Bone marrow adipose tissue, diet, ageing, & sex differences in health & disease
William Cawthorn ↗Utilising zebrafish and genetic screens to identify molecular mechanisms of adipose formation, distribution and function.
James Minchin ↗Glucocorticoid-induced adipose dysregulation. Sexually-dimorphic responses of perivascular adipose tissue to obesity.
Mark Nixon ↗Brown adipose tissue formation and function, including human studies and new imaging methods.
Roland Stimson ↗Human monogenic lipodystrophy DNA replication and repair in maintaining adipose health. Centrosome and mitochondrial function in adipose tissue.
Robert Semple ↗